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学术报告(2011-6-29)
2011-06-29 00:00   审核人:

报告题目:The bacterium Wolbachia changes host reproduction and inhibits viral infection in mosquito

报 告 人:Zhiyong Xi博士,Michigan State University(美国)

报告时间:2011年6月29日(星期三)下午 2:30—3:30

报告地点:数学与信息科学学院三楼会议室

欢迎广大师生参加!

摘 要

Diseases transmitted by blood-feeding arthropod vectors, such as mosquito-borne malaria and dengue fever, cause 1.5 million human deaths every year. The insufficiency of currently available strategies, including vaccines, drugs, and pesticides, has led to an increase in vector-borne diseases. The endosymbiotic bacterium Wolbachia is widely recognized for its potential as a vehicle to introduce disease-resistance genes into mosquitoes, making them refractory to the human pathogens they transmit. This is due to its ability to induce a reproductive abnormality known as cytoplasmic incompatibility (CI). CI is early embryo death when a Wolbachia infected male mates with a female that is uninfected or harboring a different Wolbachia type. Since uninfected males can successfully mate with infected females, Wolbachia and any gene it carries can spread quickly in a population. We recently observed that Wolbachia induces resistances to dengue virus in mosquito Aedes aegypti. This provides Wolbachia a “mosquito vaccine” like feature, which can be introduced, driven through CI, and spread over mosquito population to block transmission of mosquito-borne diseases. I will present our recent works on how Wolbachia-mosquito interactions activate Toll pathway and induce expression of anti-dengue effectors. The mosquito gene expression profile regulated by Wolbachia will be dissected in the presence and absence of dengue virus, with special focus on immune and redox genes. Finally, a three-way interactions between Wolbachia, dengue virus and mosquito host will be analyzed in mosquito protein interaction network to further understand the molecular mechanisms of Wolbachia-induced CI and viral interference. I will discuss the significance of our findings for pharmacological intervention and development of environmentally friendly biopesticides and novel strategies for future control of vector-born disease.


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